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Faculty of Dentistry
Document Details
Document Type
:
Article In Journal
Document Title
:
Interleukin-6 deficiency increases inflammatory bone destruction.
Interleukin-6 deficiency increases inflammatory bone destruction.
Document Language
:
English
Abstract
:
Periapical bone destruction occurs as a consequence of pulpal infection. In previous studies, we showed that interleukin-1 (IL-1) is the primary stimulator of bone destruction in this model. IL-6 is a pleiotropic cytokine that is induced in these infections and has both pro- and anti-inflammatory activities. In the present study, we determined the role of IL-6 in regulating IL-1 expression and bone resorption. The first molars of IL-6 knockouts (IL-6(-/-)) and wild-type mice were subjected to surgical pulp exposure and infection with a mixture of four common pulpal pathogens, including Prevotella intermedia, Fusobacterium nucleatum, Peptostreptococcus micros, and Streptococcus intermedius. Mice were killed after 21 days, and bone destruction and cytokine expression were determined. Surprisingly, bone destruction was significantly increased in IL-6(-/-) mice versus that in wild-type mice (by 30%; P < 0.001). In a second experiment, the effects of chronic (IL-6(-/-)) IL-6 deficiency and short-term IL-6 deficiency induced by in vivo antibody
ISSN
:
0
Journal Name
:
Infect Immun.
Volume
:
69
Issue Number
:
2
Publishing Year
:
2001 AH
2001 AD
Article Type
:
Article
Added Date
:
Monday, May 5, 2008
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
خالد بالطو
balto, khalid
Investigator
Doctorate
kbalto@kau.edu.sa
Files
File Name
Type
Description
Interleukin-6 deficiency increases inflammatory bone destruction.pdf
pdf
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