Document Details Document Type : Article In Journal  Document Title : Interleukin-6 deficiency increases inflammatory bone destruction. Interleukin-6 deficiency increases inflammatory bone destruction.   Document Language : English  Abstract : Periapical bone destruction occurs as a consequence of pulpal infection. In previous studies, we showed that interleukin-1 (IL-1) is the primary stimulator of bone destruction in this model. IL-6 is a pleiotropic cytokine that is induced in these infections and has both pro- and anti-inflammatory activities. In the present study, we determined the role of IL-6 in regulating IL-1 expression and bone resorption. The first molars of IL-6 knockouts (IL-6(-/-)) and wild-type mice were subjected to surgical pulp exposure and infection with a mixture of four common pulpal pathogens, including Prevotella intermedia, Fusobacterium nucleatum, Peptostreptococcus micros, and Streptococcus intermedius. Mice were killed after 21 days, and bone destruction and cytokine expression were determined. Surprisingly, bone destruction was significantly increased in IL-6(-/-) mice versus that in wild-type mice (by 30%; P < 0.001). In a second experiment, the effects of chronic (IL-6(-/-)) IL-6 deficiency and short-term IL-6 deficiency induced by in vivo antibody  ISSN : 0  Journal Name : Infect Immun.  Volume : 69  Issue Number : 2  Publishing Year : 2001 AH 2001 AD  Article Type : Article  Added Date : Monday, May 5, 2008  Researchers Researcher Name (Arabic) Researcher Name (English) Researcher Type Dr Grade Email خالد بالطو balto, khalid Investigator Doctorate kbalto@kau.edu.sa Files File Name Type Description  Interleukin-6 deficiency increases inflammatory bone destruction.pdf pdf   Back To Researches Page