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Document Details
Document Type
:
Article In Journal
Document Title
:
Theoretical optimization by genetic algorithm of delayed extraction parameters for a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer
Theoretical optimization by genetic algorithm of delayed extraction parameters for a matrix-assisted laser desorption/ionization time-of-flight mass spectrometer
Document Language
:
Arabic
Abstract
:
This paper presents the application of a genetic algorithm (GA) to optimize the operating parameters, namely pulse voltage and extraction delay time, when using matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOFMS). Simulations predict the presence of several combinations of these parameters that give a local maximum. The aim is to locate the optimal combination (a global maximum) of pulse voltage and extraction time delay in order to focus the ions of a particular m/z value to achieve the best resolution in a given instrumental geometry. The GA locates the global maximum quickly. The results indicate that it may be possible to achieve very high resolving power by using delayed extraction (DE)-MALDI-TOFMS with parameters obtained from the GA. Copyright © 2005 John Wiley & Sons, Ltd.
Journal Name
:
Rapid Communications in Mass Spectrometry
Volume
:
19
Issue Number
:
23
Publishing Year
:
2005 AH
Added Date
:
Monday, June 2, 2008
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
.
S. Tauro
Researcher
د. مير علي رازفي
S. Tauro
Researcher
mrazvi@apsara.barc.ernet.in
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