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Faculty of Dentistry
Document Details
Document Type
:
Article In Journal
Document Title
:
Attenuation of C-Reactive Protein Increases After Exodontia by Tramadol and Ibuprofen
Attenuation of C-Reactive Protein Increases After Exodontia by Tramadol and Ibuprofen
Document Language
:
English
Abstract
:
The anti-inflammatory effects of ibuprofen and tramadol were investigated by measuring C-reactive protein concentrations after removal of an impacted lower third molar. Forty-five American Society of Anesthesiologists Class I patients were randomly categorized into 3 equal groups according to postoperative analgesic medication. The first group received tramadol (lOO mg every 8 hours), the second group received ibuprofen (400 mg every 8 hours), and the last group received half doses of both drugs in combination (50 mg tramadol every 8 hours and 200 mg ibuprofen every 8 hours). C-reactive protein was measured before surgery to exclude the presence of any preexisting inflammatory condition that might interfere with the study. C-reactive protein was also determined immediately after surgery and 72 hours postoperatively. At 72 hours, C-reactive protein had increased over postsurgery baseline by 123% in the tramadol group (P < .001), 84% in the ibuprofen group (P < .001), and only 37% in the combined analgesic group (P = .078). These results suggest that tramadol may produce supra-additive anti-inflammatory effects with ibuprofen after third-molar extractions.
ISSN
:
0
Journal Name
:
the american dental society of anesthesiology
Volume
:
53
Issue Number
:
1
Publishing Year
:
2006 AH
2006 AD
Article Type
:
Article
Added Date
:
Thursday, December 6, 2007
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
ابراهيم الحكيم
Al-hakim, ibrahim
Investigator
Doctorate
ialhakeem@kau.edu.sa
Files
File Name
Type
Description
Attenuation of.pdf
pdf
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