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Document Type |
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Article In Journal |
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Document Title |
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OSSEOUS RESPONSE TO BOVINE HYDROXYAPATITE AND COLLAGEN SPONGE IN MEMBRANE. PROTECTED DEFECTS. OSSEOUS RESPONSE TO BOVINE HYDROXYAPATITE AND COLLAGEN SPONGE IN MEMBRANE. PROTECTED DEFECTS. |
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Document Language |
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English |
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Abstract |
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The aim of this study was to assess the clinical and histologic response to bovine hydroxyapatite
(osteograf/N 300) and collagen sponge in membrane protected calvarial defects as regards preserving
the contour of the defects, quality and rate of bone formation. Twelve adult male rabbits
were divided into two equal groups. Two osseous defects (right and left) of 10 mm diameter wer.e
made in the frontal bones of each rabbit. In group I, the left side defect was filled with osteograf/N
and the right side defect served as a control. In group 11,the left side defect was filled with collagen
sponge and the right defect acted as a control. All defects were covered with absorbable collagen
membranes (Biomend). Four animals (2 from each group) were euthanized after 3, 5 and 9 weeks
and specimens were prepared and sent for histologic examination. Clinically, all animals healed uneventfully
without complications, the defect in control sites showed partial collapse being filled only
with blood, while group 11showed partial collapse later due to resorption of the collagen sponge. On
the other hand, group I showed stability of the defect surface throughout the experiment. Histologically,
although osteograf/N had slow bone formation yet it was of good quality. Collagen sponge
showed faster bone formation of low quality with large amount of woven bone until the ninth week.
Particles of osteograf/N were seen throughout the experiment. The biocompatibility of both materi-'
als was confirmed, osteograf/N formed bone of better quality and maintained the restored defect dimensions.
Osteograf/N may have potential for use in the reconstruction of oral and craniofaciomaxillary
defects. Collagen sponge being biocompatible, -.yithno deleterious effect on bone
healing, has recently been used as a carrier for hr-BMP-2 to reconstruct bone defects and to restore
osseous contours. |
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ISSN |
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0 |
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Journal Name |
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Egyptian Dental Journal, |
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Volume |
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47 |
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Issue Number |
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1 |
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Publishing Year |
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2001 AH
2001 AD |
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Article Type |
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Article |
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Added Date |
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Saturday, February 20, 2010 |
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Researchers
| فاروق محمد | Mohammed, Farouk | Investigator | Doctorate | |
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