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Document Details
Document Type
:
Thesis
Document Title
:
Vitamin D Receptor Gene Haplotype and its Relation to Osteoporosis in Postmenopausal Saudi Women
النمط الفرداني لجين مستقبل فيتامين د وعلاقته بهشاشة العظام لدى السيدات السعوديات ما بعد سن انقطاع الطمث
Subject
:
Science in Biochemistry
Document Language
:
Arabic
Abstract
:
Osteoporosis affects about 48% of postmenopausal Saudi women, and this common disease has a strong genetic component. Vitamin D receptor (VDR) was the first candidate gene to be studied in this field, and most attention has been focused on polymorphisms situated on the 3’flank of VDR recognized by the restriction enzymes BsmI, ApaI and TaqI. On the other hand, since these polymorphisms are all located in intron 8 and the proximal region of exon 9, they are in strong linkage disequilibrium that allowed them to be studied as a haplotype. The relationship between VDR polymorphisms and bone mineral density (BMD) is controversial and has not been confirmed by all workers in different ethnic groups studied. In order to evaluate the contribution of the VDR alleles in bone mass loss, the Bsm-Apa-Taq haplotypes in the VDR gene were studied in eighty Saudi postmenopausal women. These women were divided into three groups according to their T-score. These groups were: normal, osteopenia and osteoporosis groups. The target region of VDR gene was isolated and amplified by the polymerase chain reaction (PCR). The products of PCR were digested by restriction enzymes: ApaI, TaqI and BsmI and electrophoresed on agarose gel. Eleven different haplotypes were found. None of the individual VDR gene polymorphisms or haplotypes displayed an association with BMD, and no significant difference was found between the groups. In conclusion, there was no relation effect between VDR gene haplotypes and BMD or osteoporosis in a sample of Saudi women.
Supervisor
:
Prof. Dr. Taha A. Kumosani
Thesis Type
:
Master Thesis
Publishing Year
:
1433 AH
2012 AD
Co-Supervisor
:
Dr. Archana P. Iyer
Added Date
:
Monday, April 2, 2012
Researchers
Researcher Name (Arabic)
Researcher Name (English)
Researcher Type
Dr Grade
Email
سها عبد العال فراج
Farraj, Suha Abdulall
Researcher
Master
Files
File Name
Type
Description
32753.pdf
pdf
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