Document Details

Document Type : Thesis 
Document Title :
VCAM-1, ICAM-1, AND E-SELECTIN AS CARDIOVASCULAR RISK MARKER IN TYPE 2 DIABETES MELLITUS.
معامل الالتصاق الخاص باالاوعية الدموية (VCAM-1) و معامل الالتصاق الخلوي (ICAM-1) و E-segectin كدلالات خطر للقلب و الاوعية الدموية في مرض السكري النوع الثاني.
 
Subject : Faculty of medicine 
Document Language : Arabic 
Abstract : Introduction: Diabetes mellitus (DM) has been recognized as a most chronic endocrine illness. About 90% of DM is type 2 diabetes mellitus (T2DM). T2DM considered the main risk factor for the development of both cardiovascular diseases (CVDs) and endothelial dysfunction. The endothelium can express after activation several adhesion molecules that are considered as mediators for the adhesion of ¬¬leukocytes to the surface of endothelium causing the development of CVD in diabetic patients. These adhesion mo¬lecules include Intercellular Adhesion Molecule-1 (ICAM-1), Vascular Cell Adhesion Molecule-1 (VCAM-1) and endothelium selectin (E-selectin). However, their associations with CVD in patients with T2DM remain inconclusive. Therefore, the aim of this study was to investigate the sE-selectin, sICAM-1 and sVCAM-1 as cardiovascular (CV) risk markers in T2DM. Subject and methods: A case-control study was conducted on 21 controls, 30 T2DM patients without CVD and 30 T2DM patients with CVD and measurement the serum levels of sICAM-1, sE-selectin and sVCAM-1 by ELISA technique was done. Result: The levels of sICAM-1, sE-selectin and sVCAM-1 were statistically significantly higher in diabetic groups than control one. Only the serum sVCAM-1 was statistically significantly higher in T2DM with CVD group than T2DM without CVD group. Conclusion: The present study showed that the levels all of serum sICAM-1, sE-selectin and sVCAM-1 were significantly higher in diabetic patients regardless they had CVD or not. Moreover, it w.as found that only a sVCAM-1 considered a useful biomarker for future prediction of CV events in T2DM patients while both of sICAM-1 and sE-selectin cannot. Furthermore, it was found the serum sVCAM-1 had a significant association with both of serum sE-selectin and serum sICAM-1 in T2DM with CVD group. 
Supervisor : Prof. Enayat Hashem 
Thesis Type : Master Thesis 
Publishing Year : 1439 AH
2018 AD 
Added Date : Tuesday, September 25, 2018 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
اسماء باشا ابوناجيAbunaji, Asmaa BashaResearcherMaster 

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