الانتقال الى المحتوى الأساسي

جامعة الملك عبدالعزيز

KING ABDULAZIZ UNIVERSITY

كلية الطب

تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
“Alterations in the ultrastructure of the liver in chronic lead intoxication in the adult albino rat”
“Alterations in the ultrastructure of the liver in chronic lead intoxication in the adult albino rat”
 
لغة الوثيقة : الانجليزية 
المستخلص : In the present work, the effect of chronic lead intoxication in two doses (5mg/kg body weight, as therapeutic dose and 10mg/kg body weight as sublethal dose) on the ultrastructure of the rat liver was studied. The rats were classified into three groups: one control group (10 rats), experimental group A (20 rats) who received a therapeutic dose of lead acetate orally for six months, and experimental group B (20 rats) who received a sublethal dose of lead acetate orally for six months. Ten rats of both groups A & B were sacrificed one month after the last given dose (recovery rats). Small slices of the liver of the rats of all groups were processed for electron microscopic examination. The livers of group A rats showed a few pathological changes in the form of proliferation of both rough and smooth endoplasmic reticulum, multiple areas of glycogen depletion with a few lysosomes and fat droplets. Group B rats showed marked pathological changes in both hepatocytes and Van Kuppfer’s cells. The cytoplasm of the hepatocytes showed intracytoplasmic vacuoles and a few degenerative granules. The recovery animals of group A showed good recovery, while those of group B showed only partial recovery. 
ردمد : 1658-3175 
اسم الدورية : Al-Azhar Medical Journal 
المجلد : 2 
العدد : 38 
سنة النشر : 2009 هـ
2009 م
 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Sunday, March 28, 2010 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
شريف حسنHassan, Sherif باحثدكتوراه 

الملفات

اسم الملفالنوعالوصف
 26227.1 1 

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