تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
LACK OF EVIDENCE OF CYTOMEGALOVIRUS INFECTION IN PATIENTS WITH HIV-NEGATIVE CASTLEMAN'S DISEASE: IMMUNOHISTOCHEMISTRY ANALYSIS
LACK OF EVIDENCE OF CYTOMEGALOVIRUS INFECTION IN PATIENTS WITH HIV-NEGATIVE CASTLEMAN'S DISEASE: IMMUNOHISTOCHEMISTRY ANALYSIS
 
لغة الوثيقة : الانجليزية 
المستخلص : BACHGROUND: Castleman's disease (CD) is a rare atypical lymphoproliferative disorder. The pathogenesis of CD is still not clear. The aim of this study is to evaluate the possible involvement of cytomegalovirus (CMV) in the pathogenesis of CD. METHOD: Immunohistochemistry for CMV was performed on archival formalin- fixed, paraffin wax embedded biopsy specimens from 25 cases of CD without human immunodeficiency virus (HIV) infection at The Toronto General Hospital, University Health Network (Toronto, Canada), King Abdulaziz University Hospital (KAUH) and King Faisal Specialist Hospital and Research Centre (KFSHRC), Jeddah, Saudi Arabia). The clinical histories were reviewed. Pathology sections (4 m) were stained using CMV monoclonal antibody (NCL-CMVpp65). The assays were performed at the Department of Pathology, KAUH in 2008. RESULTS: The age range was 16-90 years. There were 14 males and 11 females. Twenty-one patients had the localized form of CD and 4 patients had the multicentric form. Microscopic evaluation did not show any evidence of CMV inclusion. All of the cases show negative staining for CMV immunohistochemistry. CONCLUSIONS: CMV is unlikely to play a significant role in the pathogenesis of cases of HIV-negative CD. These results are consistent with the rare available reports in the literature that discuss this relation. 
ردمد : 0940-5429 
اسم الدورية : New Egyptian journal of medicine 
المجلد : 38 
العدد : 4 
سنة النشر : 2008 هـ
2008 م 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Sunday, April 11, 2010 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
جودة المغربيAl-Maghrabi, Jaudah باحث رئيسيدكتوراه 

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اسم الملفالنوعالوصف
 26417.doc doc 

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