الانتقال الى المحتوى الأساسي

جامعة الملك عبدالعزيز

KING ABDULAZIZ UNIVERSITY

كلية الطب

تفاصيل الوثيقة

نوع الوثيقة : مقال في مجلة دورية 
عنوان الوثيقة :
Circulating Levels Of Ghrelin, Leptin, Resistin And Tumor Necrosis Factor Alpha Are Novel Markers In Ulcerative Colitis
Circulating Levels Of Ghrelin, Leptin, Resistin And Tumor Necrosis Factor Alpha Are Novel Markers In Ulcerative Colitis
 
لغة الوثيقة : الانجليزية 
المستخلص : Recently adipose tissue has been regarded as a real endocrine organ that secretes many hormones, collectively known as adipokines. It has been suggested that these adipokines could play an important role in modulating body metabolism, appetite and immuno-inflammatory response, which were considered among the hallmarks of acute phase of ulcerative colitis. The present work aimed to study the plasma levels of tumor necrosis factor alpha (TNF-α), resistin, leptin and ghrelin in patients with ulcerative colitis to clarify their role in the inflammatory process and the associated anorexia and body weight loss in those patients. The study was conducted on 40 patients with ulcerative colitis (UC). Who were subdivided into 2 subgroups, 20 patients with acute ulcerative colitis (AUC), and 20 patients with remission ulcerative colitis (RUC). In addition, 20 healthy control subjects served as control group. Plasma levels of leptin, ghrelin measured using radioimmunoassay technique while resistin and TNF-α were determined by enzyme linked immunosorbant assay (ELISA) technique. The results of the present study revealed significantly increased plasma levels of resistin, ghrelin and TNF- in patients with AUC compared to both control and RUC groups (P<0.001), with a non-significant difference between the last 2 groups , (P >0.05), whereas plasma leptin level was significantly decreased in patients with AUC compared to both control and RUC groups (P<0.001), with a non-significant difference between the latter 2 groups( P >0.05). Furthermore, the positive correlation between body mass index and leptin and negative correlation with ghrelin in AUC, confirmed their role in anorexia. Positive correlation between CRP and both resistin and ghrelin and negative correlation with leptin indicate that these adipokines correlated with severity of disease. On the basis of these results it could be concluded that adipokines could play a significant role in the pathogenesis of inflammatory processes and progress of ulcerative colitis and associated loss of weight 
ردمد : 1687-1502 
اسم الدورية : EJBMB 
المجلد : 2 
العدد : 4 
سنة النشر : 2009 هـ
2009 م
 
نوع المقالة : مقالة علمية 
تاريخ الاضافة على الموقع : Saturday, May 15, 2010 

الباحثون

اسم الباحث (عربي)اسم الباحث (انجليزي)نوع الباحثالمرتبة العلميةالبريد الالكتروني
أسامة جابرGaber, Osama باحثدكتوراه 

الملفات

اسم الملفالنوعالوصف
 26667.doc doc 

الرجوع إلى صفحة الأبحاث